Intermittent fasting protects β-cell identity and function in a type-2 diabetes model (2024)

Intermittent fasting protects β-cell identity and function in a type-2 diabetes model (1) https://doi.org/10.1016/j.metabol.2024.155813 · Intermittent fasting protects β-cell identity and function in a type-2 diabetes model (2)

Journal: Metabolism, 2024, p.155813

Publisher: Elsevier BV

Authors: Sumit Patel, Zihan Yan, Maria S. Remedi

Funder National Institutes of Health

List of references

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About this publication

Number of citations 0
Number of works in the list of references 68
Journal indexed in Scopus Yes
Journal indexed in Web of Science Yes

ASJC classification

2712 Endocrinology, Diabetes and Metabolism
1310 Endocrinology
Intermittent fasting protects β-cell identity and function in a type-2 diabetes model (2024)

FAQs

Does intermittent fasting help beta cells? ›

Intermittent fasting protects β-cell identity and function in a type-2 diabetes model.

How does intermittent fasting help type 2 diabetes? ›

Do fasting diets work for type 2 diabetes remission? We know that weight loss is the key to type 2 diabetes remission. Research tells us that intermittent fasting can help people to lose weight because they tend to consume fewer calories during the eating hours than they do when they eat at any time of the day.

Do beta cells work in type 2 diabetes? ›

Beta cells are cells in the pancreas that produce and release insulin in response to blood glucose levels. In people with type 2 diabetes, beta cells have to work harder to produce enough insulin to control high blood sugar levels. This can lead to beta cells being unable to work properly to regulate blood sugar.

What is beta cell function and mass in type 2 diabetes? ›

Increased β-cell deficiency and β-cell apoptosis are observed in the pancreatic islets of patients with type 2 diabetes. At an early stage, β-cells adapt to insulin resistance, and their insulin secretion increases, but they eventually become exhausted, and the β-cell mass decreases.

How does fasting affect B cells? ›

Fasting lowers CXCL13 levels in PPs and reciprocally increases the expression in the bone marrow. This leads to the migration of naïve B cells from PPs to the bone marrow. On the other hand, GC B cells and IgA+ B cells undergo apoptosis.

How can I reset my pancreas naturally? ›

Ways to repair the pancreas naturally:
  1. Until they feel better, drink clear drinks and consume bland foods.
  2. Consume a low-fat diet until the doctor believes the pancreas is cured.
  3. Try not to consume alcohol.
  4. Take precautions when handling medications.
  5. Take antibiotics exactly as advised by the doctor.

What is the best diet for type 2 diabetes to lose weight? ›

The Mediterranean diet is considered a great choice for those with type 2 diabetes due to its focus on plant-based eating with the inclusion of poultry, and seafood. While nothing is fully restricted in this approach, the plan encourages a person to reduce the consumption of red meat, dairy, and sugary foods.

What happens if a type 2 diabetic doesn't eat? ›

If you don't eat, your blood sugar levels are lower and medication may drop them even more, which can lead to hypoglycemia. Hypoglycemia can cause you to feel shaky, pass out, or even go into a coma. When you “break” your fast by eating, you may also be more likely to develop too-high blood sugar levels.

Can type 2 diabetes be reversed permanently? ›

There's no cure for diabetes and no way to completely get rid of it. However, diabetes can be reversed in most people. Reversing diabetes means carefully managing blood sugars to a point where medications are no longer necessary, and staying at that manageable point through a healthy routine of diet and exercise.

What kills beta cells in diabetes? ›

Chronic exposure to elevated levels of glucose and free fatty acids (FFAs) causes β-cell dysfunction and may induce β-cell apoptosis in type 2 diabetes. Exposure to high glucose has dual effects, triggering initially “glucose hypersensitization” and later apoptosis, via different mechanisms.

How to repair pancreas beta cells? ›

Pancreatic beta cells that do not produce sufficient insulin in people with type 2 diabetes (T2D) are not permanently damaged during the early stages of the disease and can be restored to normal function through the removal of excess fat in the cells, according to a study entitled “Remission of Type 2 Diabetes for Two ...

What destroys beta cells in the pancreas? ›

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the immune system.

What is B cell type 2 diabetes? ›

Type 2 diabetes (T2D) occurs when insulin-producing β cells of pancreatic islets are unable to produce and/or release sufficient insulin to overcome peripheral insulin resistance, resulting in hyperglycemia.

What are the main causes of type 2 diabetes? ›

Type 2 diabetes—the most common form of diabetes—is caused by several factors, including lifestyle factors and genes.
  • Overweight, obesity, and physical inactivity. ...
  • Insulin resistance. ...
  • Genes and family history. ...
  • Insulin resistance. ...
  • Genes and family history. ...
  • Genetic mutations. ...
  • Hormonal diseases.

What is the beta cell treatment for diabetes? ›

In people with T1D, the autoimmune system destroys the pancreas's beta cells, which produce insulin. One known way to cure T1D is to replace destroyed beta cells with external cells that make insulin and protect them so that they can function for a very long time.

Is intermittent fasting good for the pancreas? ›

Fasting triggers a particular mechanism that helps beta cells in the pancreas manage glucose, according to discovery scientists at Mayo Clinic. The paper, published in Science Advances, reports that this molecular mechanism explains why intermittent fasting supports normalized glucose concentrations.

What is the best diet for beta cells? ›

Adequate stimulation of beta cells through high carbohydrate and fibre intake, and reduced oxidative tone by caloric restriction (low protein and saturated fat), supplementation with antioxidants (vitamin E and D) and polyunsaturated essential fatty acids may prevent loss or even restore the beta-cell activity from ...

How can I improve my beta-cell function? ›

Diet and physical exercise

Weight gain and physical inactivity cause insulin resistance, placing an increased insulin secretory demand on β-cells. Conversely, weight loss (70) and exercise (71) enhance insulin sensitivity, improve glucose tolerance, and reduce the workload of β-cells.

How to regenerate pancreas beta cells naturally? ›

...a fasting-mimicking diet (FMD) can promote the regeneration of insulin-producing β cells... The reprogramming of pancreatic β cells to restore insulin production has been proposed as a potential therapeutic strategy for type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).

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